Rational Polytherapy with Antiepileptic Drugs
نویسندگان
چکیده
منابع مشابه
Rational Polytherapy with Antiepileptic Drugs
Approximately 30-40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies ...
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The global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as adjunctive treatment in refractory epilepsy has triggered an increased interest in optimising combination therapy. With a widening range of available mechanisms of AED action, much activity has been focused on the defining and refining "rational polytherapy" with AEDs that have differing pharmacological prope...
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For patients with epilepsy, the goal of treatment is to achieve seizure freedom with minimal or no adverse events. Around 60%-70% of newly diagnosed patients will achieve this goal with single antiepileptic drug (AED) therapy, and there is universal agreement that prescription of a single agent constitutes best practice for such patients. For the 30%-40% of patients with poorly controlled epile...
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Although monotherapy in epilepsy treatment is frequently advocated, this is not based on studies with equal drug loads. This study was performed to investigate the experimental background of polytherapy with standardized drug loads. Dose-dependent effects on grip strength, accelerod performance, and spontaneous behavior of rats was used to study the effect of combining valproate and ethosuximid...
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ژورنال
عنوان ژورنال: Pharmaceuticals
سال: 2010
ISSN: 1424-8247
DOI: 10.3390/ph3082362